Synthesis and Pharmacology of Benzoxazines as Highly Selective Antagonists at M4Muscarinic Receptors.
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چکیده
منابع مشابه
Synthesis of phenoxyacetic acid derivatives as highly potent antagonists of gastrin/cholecystokinin-B receptors. II.
A series of phenoxyacetanilide derivatives was synthesized and their antagonist activities for human gastrin/cholecystokinin (CCK)-B and CCK-A receptors were evaluated. Among the compounds synthesized, 2-[3-[3-[N-[2-(N-methyl-N-phenylcarbamoylmethoxy)phenyl]-N-(N-meth yl-N- phenylcarbamoylmethyl)carbamoylmethyl]-ureido]phenyl]acetic acid (20i, DA-3934) exhibited high affinity for gastrin/CCK-B ...
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Synthesis of Selective 5-HT7 Receptor Antagonists
The 5-HT7 receptor is the most recent addition to the 5-HT receptor family and has been linked to a variety of physiological and pathophysiological processes. Well established antidepressant pharmaceuticals have recently been found to activate the 5-HT7 receptor, supporting the role of the 5-HT7 receptor in the antidepressant mechanism. The synthesis of potent selective 5-HT7 receptor antagonis...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2002
ISSN: 0022-2623,1520-4804
DOI: 10.1021/jm020996j